Advanced in vitro cancer models

Cancer metastases represent the greatest challenge of modern medicine due to their high impact on patient mortality. Our lab studies the metastatic process through 2D and 3D human in vitro models across multiple scales. We successfully  design  and  develop human  vascularized  macro and microfluidic systems that mimic in vivo biophysical and biochemical organ specific microenvironment with the aim to study different steps of metastasis. Particularly, we are able to analyze the crosstalk between breast cancer and endothelial cells in organ specific microenvironments through the establishment of endothelial monolayers or perfusable microvascular networks. We study the gene silencing effect in each step of extravasation, which can be dissected in adhesion, trans-endothelial migration and early invasion of secondary organs leading to metastatic colonization.


NEWS / EVENTS

12/12/2016 Mara Gilardi awarded with a FIRC Foundation annual scholarship for Moores Cancer Center (San Diego, CA, USA)
We are proud to announce that CTE-Lab PhD student Mara Gilardi has been awarded with a scholarship from the FIRC Foundation to spend one year at the Moores Cancer Center (UC San Diego Health Science,
08/12/2016 Meet us at TERMIS-AM 11, 14 December 2016 San Diego, CA, USA
American Chapter Meeting of the Tissue Engineering and Regenerative Medicine International Society 2016
13/05/2016 Meet us at TERMIS-EU 2016, 28 June - 1 July, 2016 Uppsala, Sweden
European Chapter Meeting of the Tissue Engineering and Regenerative Medicine International Society 2016
10/11/2015 Best Poster Award at Biofabrication 2015
We are proud to announce that the CTE-Lab, in collaboration with Yokohama National University, is the winner of the Best Poster Award of the Biofabrication Congress 2015 for the work “The surface desi
04/11/2015 Congratulations Simone Bersini!
We are proud to announce that CTE-Lab Post-Doc Simone Bersini has been awarded with the GNB Alberto Mazzoldi Doctoral Prize for the PhD Thesis entitled “Engineered Micro and Macroscale Human 3D Vascul

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